Dopamine metabolism & DOPAL Oxidative stress
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A corticostriatal gene co-expression module positively correlated with dopaminergic disturbance was specifically enriched for reactive oxygen species and hydrogen peroxide response genes, directly linking dopamine loss to an oxidative stress transcriptional signature.
The midnightblue module was positively correlated with 6-OHDA treatment and associated with oxidative phosphorylation, response to reactive oxygen species, and response to hydrogen peroxide.