health

← SNCA · ← REM sleep behaviour disorder

SNCA ↔ REM sleep behaviour disorder

1 article connects these topics

• The 5′ UTR SNCA variant rs3756059, which reached genome-wide significance in this PD GWAS, was previously identified in GWAS of REM sleep behaviour disorder and PD with RBD.

  from Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan · 2026-05-25

  We also identified evidence for a possible secondary 5′ SNCA signal, including rs3756059, a variant previously implicated in RBD and PD with RBD. This observation raises the possibility that 5′ regulatory variation at SNCA may contribute not only to PD susceptibility but also to phenotypic heterogeneity.