Gut-brain axis
Vagal-nerve spread, gut-microbiome changes and enteric alpha-synuclein pathology.
State of the art
No update yet for Gut-brain axis. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Safety and efficacy of faecal microbiota transplantation in Parkinson’s disease
The review provides the most comprehensive human-trial summary to date of attempts to intervene on the gut-brain axis in Parkinson's via FMT, finding that gut microbiome composition does shift after transplant (most consistently an increase in Firmicutes), but that these shifts have not yet translated into reliable clinical benefit for motor or most non-motor symptoms in controlled trials. -
Prebiotics balance gut bacteria and show results in Parkinson’s blood
The study provides first-in-kind evidence that extracellular vesicles in blood carry both human and bacterial proteins that reflect gut-microbiome composition in Parkinson's, and that correcting dysbiosis with prebiotics normalises these circulating signals — adding a mechanistic link between gut-barrier integrity, immune activation, and the gut-brain axis in PD.