Sleep
REM sleep behaviour disorder (RBD), insomnia, daytime sleepiness and sleep-related interventions.
In this category
State of the art
No update yet for Sleep. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan REM sleep behaviour disorder
The Taiwan GWAS independently replicates genome-wide significance for rs3756059, a 5′ UTR SNCA variant previously identified in GWAS of REM sleep behaviour disorder (RBD) and PD with RBD, raising the possibility that 5′ SNCA regulatory variation contributes to phenotypic heterogeneity including the RBD prodrome. -
Parkinson’s disease: tai chi may help manage symptoms – new research
Sleep quality was tracked across 3.5 years as part of a broad non-motor assessment; the tai chi group fared better than non-exercising controls, providing some of the longest-duration observational support yet for exercise-based approaches to PD sleep symptoms. -
Démence à corps de Lewy : voici pourquoi elle est confondue avec Parkinson et Alzheimer (et ce que ça change) - Cap Retraite REM sleep behaviour disorder
The article describes REM sleep behaviour disorder (physically acting out dreams) as an important early warning sign of LBD that can appear years before cognitive or motor symptoms — framing it as a diagnostic flag for families to bring to their neurologist, particularly when combined with fluctuating alertness or early hallucinations. -
Vyalev eases motor, nonmotor symptoms in advanced Parkinson’s Insomnia
ROSSINI interim results reported significant improvement in sleep disturbances after six months of 24-hour Vyalev infusion in advanced Parkinson's, suggesting that stabilising overnight levodopa levels may contribute to better sleep in this population. -
Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson’s disease and multiple system atrophy
The Heads-Up trial provides the first randomised evidence that a positional sleeping intervention — raising the entire bed frame head-end by 6°–18° — can improve overnight blood-pressure regulation in PD and MSA. Sleep position adherence was high at moderate angles (100% at 6°, 80% at 12°), suggesting the approach is practically feasible as a nightly routine, though comfort becomes the limiting factor at steeper angles. -
The biological clock in parkinson’s disease: mechanisms and chronotherapy
Reframes the sleep problems common in PD (insomnia, excessive daytime sleepiness, REM sleep behaviour disorder) as part of a broader circadian-system breakdown that may itself accelerate the disease — meaning protecting sleep regularity could be more than symptom relief. Specific chronobiological interventions discussed include bright-light therapy and melatonin-pathway approaches, though none has yet matured into a standard-of-care recommendation. -
Parkinson's Disease.
REM sleep behavior disorder (RBD)—in which people physically act out vivid dreams—is highlighted as one of the strongest prodromal markers of Parkinson's and related synucleinopathies, often preceding motor diagnosis by a decade or more. The article situates RBD within the new biological staging system as evidence of early neurological involvement.